Orta kulak cerrahisi sonrasında oluşan bulantı ve kusmada droperidol, metoklopramid, propofol ve ondansetronun etkinliği
Turgut Karlıdağ, İrfan Kaygusuz, Azize Bestaş, Erol Keleş, Erhan Demirbağ, Şinasi Yalçın
FREE FULL TEXT Anahtar Kelimeler: Anestezi, genel; antiemetik/terapötik kullan ı m;droperidol/terapötik kullanım; kulak, orta/cerrahi; metoklopramid/ terapötikkullanım; ondansetron/terapötik kullanım; ameliyat sonrasıbulantı ve kusma/önleme ve kontrol; propofol/terapötik kullanım.
The efficacy of droperidol, metoclopramide, propofol and ondansetron for the prevention of nausea and vomiting following middle ear surgery
Turgut Karlıdağ, İrfan Kaygusuz, Azize Bestaş, Erol Keleş, Erhan Demirbağ, Şinasi Yalçın
Objectives: The efficacy and reliability of prophylactic antiemetic
therapy with low dose propofol, droperidol, metoclopramide
and ondansetron were evaluated in a randomized, doubleblind,
and prospective design.
Patients and Methods: A total of 101 ASA I-II patients (34
females, 67 males; age range 16 to 53 years) undergoing
middle ear surgery for chronic otitis media or its sequelae
were randomly assigned to receive prophylactic antiemetic
therapy with propofol (n=21, 0.5 mg/kg), droperidol (n=19, 20
mg/kg), metoclopramide (n=23, 0.2 mg/kg), ondansetron
(n=21, 4 mg), and placebo (n=20, 0.9% NaCl). All drugs were
administered intravenously five minutes before extubation.
Resul t s: In the early postoperative period (0 to 3 hours), the
percentages of patients free from nausea and vomiting were
100% with droperidol, 71.4% with ondansetron and propofol,
52.1% with metoclopramide, and 35% with placebo.
Ondansetron (90.4%) was found the most effective to prevent
and control nausea and vomiting during the postoperative
3 to 24 hours, followed by droperidol (84.2%), propofol
(57.1%), metoclopramide (47.8%), and placebo (40%).
Compared with controls, the number of patients without nausea
and vomiting was significantly greater in each treatment
group but metoclopramide (p<0.05). No significant differences
were detected with respect to adverse effects.
Conclusion: Droperidol and ondansetron seem to exert the
highest efficacy to prevent nausea and vomiting during the
postoperative 0 to 3 hours and 3 to 24 hours, respectively. Key words: Anesthesia, general; antiemetics/therapeutic use;droperidol/therapeutic use; ear, middle/surgery; metoclopramide/therapeutic use; ondansetron/therapeutic use; postoperative nauseaand vomiting/prevention & control; propofol/therapeutic use.
Turgut Karlıdağ, İrfan Kaygusuz, Azize Bestaş, Erol Keleş, Erhan Demirbağ, Şinasi Yalçın. The efficacy of droperidol, metoclopramide, propofol and ondansetron for the prevention of nausea and vomiting following middle ear surgery. Kulak Burun Bogaz Ihtis Derg. 2002; 9(5): 331-336
Corresponding Author: Turgut Karlıdağ |
